In this pilot study, we found a list of genes significantly down-regulated in the peripheral blood in the rejection states in three small-bowel-transplant patients. Our hypothesis, derived from this project, is that down-regulation of translation in peripheral blood mononuclear cells occurs early during the course of rejection and correlates with the severity of the rejection episode as determined by concurrent graft biopsies. Presented at: International Conference on Systems Biology 2010.
Victor P. Andreev, Panagiotis Tryphonopoulos, Phillip Ruiz, Nicholas F. Tsinoremas, Bonnie Blomberg, Andreas G. Tzakis
Informatics Forum, School of Informatics, University of Edinburgh
10 Crichton Street, Edinburgh, Scotland EH8 9AB | October 10-15, 2010