Publications
Protemic Cellular Signatures of Kinase Inhibitor-Induced Cardiotoxicity: Mount Sinai…
Abstract The Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that can predict adverse effects, especially cardiotoxicity, of kinase inhibitors approved by the Food and Drug Administration. Read more “Protemic Cellular Signatures of Kinase Inhibitor-Induced Cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset”
![Fig. 2 Spatial DWH cumulative extents. (A) Cumulative NESDIS anomaly daily composites integrated from 20 April 2010 to 21 July 2010. Daily fishing closures are marked with gray lines; the cumulative fishing closure area is marked with a thick dashed yellow line. The black star represents the location of the DWH blowout [adapted by permission from Springer-Nature: Scenarios and Responses to Future Deep Oil Spills: Fighting the Next War by S. Murawski, C. Ainsworth, S. Gilbert, D. Hollander, C. Paris, M. Schlüter, D. Wetzel, Eds., 2019 (18)]. (B) Cumulative value of daily average oil concentrations (ppb), integrated across the same time span as (A) and across water depths. Vertical depth layers are 0 to 1 m, 1 to 20 m, and in 20-m increments down to 2500 m. Sediment and water samples with higher-than-background concentration are marked in bright green and dark blue circles, respectively [adapted by permission from Springer-Nature: Scenarios and Responses to Future Deep Oil Spills: Fighting the Next War by S. Murawski, C. Ainsworth, S. Gilbert, D. Hollander, C. Paris, M. Schlüter, D. Wetzel, Eds., 2019 (18)]. Red crosses in (B) represent approximate locations of DWH-related oil detections reported in previous studies: (i) (9), (ii) (7), (iii) (12), (iv) (13), and (v) (15). Daily fishery closures are marked with black polygons; the cumulative fishery closure area is marked with a dashed thick polygon. AB, Apalachee Bay; DP, Deep Plume; EFS, East Florida Shelf; FK, Florida Keys; LC, Loop Current System; TXS, Texas Shores; WFS, West Florida Shelf. (C) Categorization of the modeled oil spill are as follows: (i) nontoxic, PAH concentrations above background level and smaller than 0.5 and 1 ppb at the surface (depth, 0 to 1 m) and in the water column (depth, >1 m), respectively; (ii) toxic-to-biota and invisible, PAH concentrations 0.5 to 17 ppb at the surface and above 1 ppb in the water column; and (iii) toxic and visible, PAH concentrations above 17 ppb. In (C), categories were computed according to maximal concentrations across time. (D) Duration of toxic concentrations across the domain. (E) LC50 of 12 experiments examining the photoinduced toxicity to blue crab (31), fiddler crab (33), mahi mahi (29, 30), red drum (32), and speckled sea trout (32) (for more details, see table S2). (F) The spatial extent of the toxic concentrations from (E); color codes in (F) are according to bar colors in (E), representing concentrations exceeding LC50. In (F), toxic PAH of 0.5 ppb was concentrations were considered for surface waters only (depth, 0 to 1 m).](https://i0.wp.com/idsc.miami.edu/wp-content/uploads/2021/03/Spatial-cumulative-extents-of-the-Deepwater-Horizon-oil-spill-Berenshtein-et-al-2020-Science-Advances.jpg?resize=730%2C350&ssl=1)
