Distinct Transcriptomic Features and B-Cell Populations in the Mouse…
Splenic transitional B-cells (T1 and T2) are selected to avoid self-reactivity and to safeguard against autoimmunity, then differentiate into mature follicular (FO-I and FO-II) and marginal zone (MZ) subsets. Transcriptomic analysis by RNA-seq of the five B-cell subsets revealed T1 cell signature genes included RAG suggesting a potential for receptor revision. Read more “Distinct Transcriptomic Features and B-Cell Populations in the Mouse Spleen”