John Bixby – Frost Institute for Data Science & Computing

Fast-Tracked Early Warning COVID-19 Research Project

April 13, 2020April 13, 2020

Twenty-four University of Miami research teams, including a team from IDSC, have received rapid-response grants to undertake innovative projects that will provide critical information about the novel coronavirus. Imagine developing an oral rinse test to detect COVID-19 earlier, creating a behavior therapy program for parents so that they do not pass on the stress they are feeling to their children during the pandemic, or gauging the effects of COVID-19 on pregnant women and trying to determine the impacts on their new babies. Read more “Fast-Tracked Early Warning COVID-19 Research Project” →

FAIR SCI Ahead: The Evolution of the Open Data…

March 15, 2020January 4, 2021

Over the last 5 years, multiple stakeholders in the field of spinal cord injury (SCI) research have initiated efforts to promote publications standards and enable sharing of experimental data. In 2016, the National Institutes of Health/National Institute of Neurological Disorders and Stroke hosted representatives from the SCI community to streamline these efforts and Read more “FAIR SCI Ahead: The Evolution of the Open Data Commons for Pre-Clinical Spinal Cord Injury Research” →

Epigenomic Signatures Underpin the Axonal Regenerative Ability of Dorsal…

October 7, 2019March 26, 2021

Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Read more “Epigenomic Signatures Underpin the Axonal Regenerative Ability of Dorsal Root Ganglia Sensory Neurons” →

PP4-Dependent HDAC3 Dephosphorylation Discriminates Between Axonal Regenartion and Regenerative…

May 22, 2019July 22, 2022

The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord injury does not. Read more “PP4-Dependent HDAC3 Dephosphorylation Discriminates Between Axonal Regenartion and Regenerative Failure” →

Snapshots of Data Science in Action

April 18, 2019August 4, 2023

Across the University of Miami’s three campuses, faculty and students are immersed in research aimed at providing shape and solutions to some of the world’s most pressing issues. Helping to solve some of the riddles is the use of data science—big batches of information filtered through high-performance computers that aid researchers in their efforts to decipher complex formulas and create predictive applications. Here’s a look at some of the ongoing work: Read more “Snapshots of Data Science in Action” →

Plotting the Future Through Data

April 16, 2019August 4, 2023

Data. Although it is a short word, often dismissed as numbers or statistics, it follows us everywhere today. From the steps that we take, to our traffic patterns and driving speeds, to identifying our genomic sequence and even our daily purchasing habits. And more each day, governments, schools, and businesses are seeing the benefits of this information. Read more “Plotting the Future Through Data” →

Can Chromatin Accessibility be Exploited for Axon Regeneration?

April 17, 2018December 29, 2020

Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest . . . Read more “Can Chromatin Accessibility be Exploited for Axon Regeneration?” →