The Scripps Research Institute – Frost Institute for Data Science & Computing

Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated…

September 4, 2011August 4, 2023

PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of anti-diabetes drugs including rosiglitazone and pioglitazone. These drugs are full classical agonists for this nuclear receptor, but recent data have shown that many PPARγ-based drugs have a separate biochemical activity, blocking the obesity-linked phosphorylation of PPARγ by Cdk5. Read more →

Featured Scientist Zhijie Jiang, PhD

June 28, 2011July 28, 2023

Dr. Zhijie Jiang received his PhD in Evolutionary Biology from Louisiana State University in 2006, and then spent one year working on genome annotation projects at Scripps, Florida (The Scripps Research Institute). His main projects at CCS can be divided into two categories: The first is genome assembling using next generation sequencing (NGS) data and genome annotation, his expertise includes both prokaryotic and eukaryotic genomes, run on two different NGS platforms; the second focus is gene expression analysis, working with microarray data as well as NGS data. This latter focus allows him to maintain an active interest in gene regulatory networks and promoter prediction.

Tag: The Scripps Research Institute

Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated…

Featured Scientist Zhijie Jiang, PhD