News - Archived
Congratulations to Drs. Stephan Schurer, Vance Lemmon, Ubbo Visser, and the Cheminformatics Group, recipients of NIH funding for their proposal entitled “LINCS Information FramEwork (LIFE) to Integrate and Analyze Diverse Data set”. This project proposes to develop a novel information system that will help scientists to access and use information generated by the NIH LINCS project and other public data sources. Read more “NIH funds “LIFE””
Presentations - Archived
In this pilot study, we found a list of genes significantly down-regulated in the peripheral blood in the rejection states in three small-bowel-transplant patients. Our hypothesis, derived from this project, is that down-regulation of translation in peripheral blood mononuclear cells occurs early during the course of rejection and correlates with the severity of the rejection episode as determined by concurrent graft biopsies. Presented at: International Conference on Systems Biology 2010. Read more “Pathway Analysis for Discovery of Rejection Mechanism and Biomarkers in Intestinal Transplantation”
Publications
PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of anti-diabetes drugs including rosiglitazone and pioglitazone. These drugs are full classical agonists for this nuclear receptor, but recent data have shown that many PPARγ-based drugs have a separate biochemical activity, blocking the obesity-linked phosphorylation of PPARγ by Cdk5. Read more “Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation”