![Figure 1:. Diagram summarizing the effects on chromatin accessibility of three axon regeneration-promoting interventions. A) PTEN in a complex with nucleosomes. Deletion of PTEN prevents the binding of Histone H1 to DNA and thereby promotes chromatin accessibility. B) Enhancement of neuronal activity induces expression of AP-1 factors, mediating chromatin opening and activating transcription. C) Overexpression of TET enzymes catalyzes conversion of 5-methylcytosine (5mc) to 5-hydroxymethylcytosine (5hmc), thereby promoting chromatin opening.](https://i0.wp.com/idsc.miami.edu/wp-content/uploads/2020/12/nihms-1033291-f0001-940x530-1.jpg?resize=730%2C350&ssl=1)
Can Chromatin Accessibility be Exploited for Axon Regeneration?
Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest . . . Read more “Can Chromatin Accessibility be Exploited for Axon Regeneration?”