PPARγ is the functioning receptor for the thiazolidinedione (TZD) class of anti-diabetes drugs including rosiglitazone and pioglitazone. These drugs are full classical agonists for this nuclear receptor, but recent data have shown that many PPARγ-based drugs have a separate biochemical activity, blocking the obesity-linked phosphorylation of PPARγ by Cdk5. Read more “Anti-Diabetic Actions of a Non-Agonist PPARγ Ligand Blocking Cdk5-Mediated Phosphorylation”
Dr. Neil F. Johnson heads a new interdisciplinary research group in Complexity in the Department of Physics at the University of Miami. The research focuses on collective behavior and emergent properties in a wide range of real-world Complex Systems: from the physical, biological, medical domains through to social and even financial domains.