Identification of BRAF 3’UTR Isoforms in Melanoma

BRAF protein kinase is a crucial player in melanoma, as it belongs to the highly oncogenic RAS/RAF/MEK/ERK signaling pathway (Matallanas et al., 2011), is mutated in about 50% of melanoma cases (Cantwell-Dorris et al., 2011), is causally linked to melanomagenesis (Dankort et al., 2009) and has recently become a valuable therapeutic target against metastatic melanoma (Menzies and Long, 2014). Read more “Identification of BRAF 3’UTR Isoforms in Melanoma” →