Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Read more “Epigenomic Signatures Underpin the Axonal Regenerative Ability of Dorsal Root Ganglia Sensory Neurons”
The molecular mechanisms discriminating between regenerative failure and success remain elusive. While a regeneration-competent peripheral nerve injury mounts a regenerative gene expression response in bipolar dorsal root ganglia (DRG) sensory neurons, a regeneration-incompetent central spinal cord injury does not. Read more “PP4-Dependent HDAC3 Dephosphorylation Discriminates Between Axonal Regenartion and Regenerative Failure”
Axon regeneration is a necessary step toward functional recovery after spinal cord injury. The AP-1 transcription factor c-Jun has long been known to play an important role in directing the transcriptional response of Dorsal Root Ganglion (DRG) neurons to peripheral axotomy that results in successful axon regeneration. Read more “The Effect of Jun Dimerization on Neurite Outgrowth and Motif Binding”
Several studies have demonstrated that the intrinsic ability of neurons to regenerate their axons can be stimulated by maneuvers that favor the open state of chromatin, such as inhibiting histone deacetylase activity or increasing histone acetyltransferase activity. Taken together, these experiments suggest . . . Read more “Can Chromatin Accessibility be Exploited for Axon Regeneration?”
This year’s IDSC Fellows presented their projects on Friday, April 29, 2016. The projects were on vastly different topics, highlighting the reach that computational science has on present-day research. Above is a sample from their presentations. Read more “IDSC Fellows Present Their Final Projects”