![Figure 4 Dusp14 regulates axon regeneration through dephosphorylation of the MAPK family in vivo. (A) No change in Dusp14 expression was detectable at 5 and 14 days after optic nerve crush. (B) Dusp14 expression decreased after intravitreal injection of AAV2-Dusp14-shRNA in vivo (arrows). (C–F) Dusp14 knockdown significantly increased the number of pERK1/2-positive cells (D) and pERK1/2 fluorescent intensity (E) in retinas treated with BDNF. (*P < 0.05, Student's t-test; n = 4 [D, E]) Scale bars: 25 μm in (A) to (C), 500 μm in (D). Error bars, SEM.](https://i0.wp.com/idsc.miami.edu/wp-content/uploads/2020/12/axon-regeneration-940x530-1.jpg?resize=730%2C350&ssl=1)
The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth…
Adult central nervous system (CNS) neurons are unable to regenerate their axons after injury. Krüppel-like transcription factor (KLF) family members regulate intrinsic axon growth ability in vitro and in vivo, but mechanisms downstream of these transcription factors are not known. Read more “The Krüppel-Like Factor Gene Target Dusp14 Regulates Axon Growth and Regeneration”