Spectrogram and other time-frequency analysis methods transfer an audio file into an auditory image. When signal processing-based analysis and interpretation is performed on these auditory images instead of an audio signal, spectrographic analyses can identify interesting patterns that focus on Read more “A New Auditory Image for Social Media: Moving Towards Correlation of Spectrographic Analysis . . .”
Clinical efficacy of targeted signaling inhibitors for hematologic malignancies is limited by outgrowth of subpopulations with alternative pathways independent of the drug target. The eIF4F complex responsible for translation initiation is a convergence point for cancer-promoting signaling pathways and its inhibition leads to decreased expression of key oncoproteins and apoptosis. Read more “Identification of Tractable Drug-Like elF4AI Inhibitors with Potent Anti-Tumor Activity”
Glioblastoma (GBM) is the most common and malignant adult brain tumor. Despite years of research, few advancements have been made in its management. One promising avenue of research has been treatment with BRD4 inhibitors, which decrease oncogene expression in GBM cells. Read more “Gene 36. Integrating Transcriptomics and Kinomics Identifies Synergistic Drug Combinations for Glioblastoma Treatment”
Glioblastoma (GBM) remains the most common adult brain tumor, with poor survival expectations, and no new therapeutic modalities approved in the last decade. Our laboratories have recently demonstrated that the integration of a transcriptional disease signature obtained from Read more “Comp-16. Comprehensive Transcriptomic Analysis of Single Cells From Recurrent and Primary Glioblastoma to Predict Cell-Type-Specific Therapeutics”
The sinking of the cargo ship SS El Faro is investigated by providing a comprehensive analysis of the wind, wave, and ocean currents associated with Hurricane Joaquin. Using state-of-the-art reanalyses, the event is assessed in high resolution and from a long-term climate perspective. Read more “Extreme Environmental Forcing on the Container Ship SS El Faro”
South Florida resource management, particularly the Everglades restoration effort, is beginning to consider projections of precipitation from multiple climate models for decision‐making. Because precipitation changes can significantly affect the Everglades ecosystem, Read more “Assessment of Uncertainty in Multi-Model Means of Downscaled South Florida Precipitation for Projected (2019-2099) Climate”
iLINCS (http://ilincs.org) is an integrative web-based platform for analysis of omics data and signatures of cellular perturbations. The portal facilitates analysis of user-submitted omics signatures of diseases and cellular perturbations in the context of a large compendium of pre-computed signatures (>200,000), Read more “Connecting Omics Signatures of Diseases, Drugs, and Mechanisms of Actions with iLINCS”
Modern human-computer interaction systems use multiple perceptual dimensions to enhance intuition and efficiency of the user by improving their situational awareness. A signal processing and interaction framework is proposed for auralizing signal patterns and augmenting the visualization-focused analysis tasks of social media content analysis and annotations, with the goal of assisting the user in analyzing, retrieving, and organizing relevant information for marketing research. Read more “Multi-Scale Auralization for Multimedia Analytical Feature Interaction”
Axonal injury results in regenerative success or failure, depending on whether the axon lies in the peripheral or the CNS, respectively. The present study addresses whether epigenetic signatures in dorsal root ganglia discriminate between regenerative and non-regenerative axonal injury. Read more “Epigenomic Signatures Underpin the Axonal Regenerative Ability of Dorsal Root Ganglia Sensory Neurons”
The Subseasonal Experiment (SubX) is a multimodel subseasonal prediction experiment designed around operational requirements with the goal of improving subseasonal forecasts. Seven global models have produced 17 years of retrospective (re)forecasts and more than a year of weekly real-time forecasts. Read more “The Subseasonal Experiment (SubX): A Multimodel Subseasonal Prediction Experiment”