Stephan Schurer – Frost Institute for Data Science & Computing

News

IDSC is Pleased to Announce 3 New Digital Health…

Expanding with the pace of innovations in health care, the IDSC Digital Health and Life Sciences Informatics program encompasses research in Digital Drug Discovery, Population Health Informatics, and Social and Behavioral Data Science. IDSC is pleased to announce the appointment of Stephan Schürer, Azizi Seixas, and Daniel Messinger as Program Directors, respectively, for these initiatives. Read more “IDSC is Pleased to Announce 3 New Digital Health and Life Sciences Directors” →

WSBO-2021: Synergizing Biomedical Ontologies Workshop 7/14-15

This workshop is dedicated to developing tools/APIs for mapping or synergizing biomedical ontologies in ways that fit the current, modernized, technology era. Conversations will be around the best practices, with an emphasis on collaborative development and dynamic workflows. Read more “WSBO-2021: Synergizing Biomedical Ontologies Workshop 7/14-15” →

News

Researchers Broaden Tracking of COVID-19 Through Wastewater

Although it is still challenging to prevent the transmission of COVID-19, researchers at the University of Miami are using all the strategies they can to fend off the spread. That includes using cutting-edge research to detect SARS-CoV-2—the virus that causes COVID-19—in wastewater*. Read more “Researchers Broaden Tracking of COVID-19 Through Wastewater” →

News

WSBO-2021: Synergizing Biomedical Ontologies Workshop 7/14-16

Publications

The Clinical Kinase Index: Prioritizing Understudied Kinases at Targets…

Abstract The approval of the first kinase inhibitor, Gleevec, ushered in a paradigm shift for oncological treatment-the use of genomic data for targeted, efficacious therapies. Since then, over 48 additional small-molecule kinase inhibitors have been approved, solidifying the case for kinases as a highly druggable and attractive target class. Read more “The Clinical Kinase Index: Prioritizing Understudied Kinases at Targets for the Treatment of Cancer” →

Research

Novel Platform Connects Users and Developers of Scientific Vocabularies

OntoloBridge, a new platform designed to bridge the gap between regular users of controlled scientific vocabularies and the creators of underlying ontologies, has been developed under a collaborative U01 grant by the University of Miami, Stanford University, and Collaborative Drug Discovery (CDD). The novel platform is now available through the BioPortal Ontology Repository. Read more “Novel Platform Connects Users and Developers of Scientific Vocabularies” →

Publications

piNET: A Versatile Web Platform for Downstream Analysis and…

Rapid progress in proteomics and large-scale profiling of biological systems at the protein level necessitates the continued development of efficient computational tools for the analysis and interpretation of proteomics data. Here, we present the piNET server that facilitates integrated annotation, analysis and visualization of quantitative proteomics data, with emphasis on PTM networks and integration with the LINCS library of chemical and genetic perturbation signatures in order to provide further mechanistic and functional insights. Read more “piNET: A Versatile Web Platform for Downstream Analysis and Visualization of Proteomics Data” →

Publications

Protemic Cellular Signatures of Kinase Inhibitor-Induced Cardiotoxicity: Mount Sinai…

Abstract The Drug Toxicity Signature Generation Center (DToxS) at the Icahn School of Medicine at Mount Sinai is one of the centers of the NIH Library of Integrated Network-Based Cellular Signatures (LINCS) program. A key aim of DToxS is to generate both proteomic and transcriptomic signatures that can predict adverse effects, especially cardiotoxicity, of kinase inhibitors approved by the Food and Drug Administration. Read more “Protemic Cellular Signatures of Kinase Inhibitor-Induced Cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset” →

Publications

Interventional Treatment of Incomplete Seal After Transcatheter or Surgical…

Transcatheter closure of the left atrial appendage (LAA) for stroke prevention has emerged as an alternative to systemic anticoagulation in patients with atrial fibrillation (AF) and increased stroke risk. Prophylactic occlusion or excision of the LAA during heart surgery in patients with AF has been performed for decades and may be considered in patients undergoing cardiac surgery. Read more “Interventional Treatment of Incomplete Seal After Transcatheter or Surgical Left Atrial Appendage Closure” →

Publications

LINCS Data Portal 2.0: Next Generation Access Point for…

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalog of perturbation-response signatures by utilizing a diverse collection of perturbations across many model systems and assay types. The LINCS Data Portal (LDP) has been the primary access point for the compendium of LINCS data and has been widely utilized. Read more “LINCS Data Portal 2.0: Next Generation Access Point for Perturbation-Response Signatures” →

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