LINCS – Frost Institute for Data Science & Computing

LINCS Data Portal 2.0: Next Generation Access Point for…

The Library of Integrated Network-Based Cellular Signatures (LINCS) is an NIH Common Fund program with the goal of generating a large-scale and comprehensive catalog of perturbation-response signatures by utilizing a diverse collection of perturbations across many model systems and assay types. The LINCS Data Portal (LDP) has been the primary access point for the compendium of LINCS data and has been widely utilized. Read more “LINCS Data Portal 2.0: Next Generation Access Point for Perturbation-Response Signatures” →

News

Comp-16. Comprehensive Transcriptomic Analysis of Single Cells From Recurrent…

Glioblastoma (GBM) remains the most common adult brain tumor, with poor survival expectations, and no new therapeutic modalities approved in the last decade. Our laboratories have recently demonstrated that the integration of a transcriptional disease signature obtained from Read more “Comp-16. Comprehensive Transcriptomic Analysis of Single Cells From Recurrent and Primary Glioblastoma to Predict Cell-Type-Specific Therapeutics” →

News

LINCS Data Portal 2.0 Update with New Functionalities

In this first major update of the portal (available at http://lincsportal.ccs.miami.edu/signatures), substantial changes in both the data architecture, and the user interface, are being introduced to enable a deeper exploration of the LINCS data, and to support new integrative and analytical capabilities for both computational and non-computational researchers. The cornerstone of this update has been the decision to reprocess all high-level LINCS datasets and make them accessible at the data-point level enabling users to directly access and download any subset of signatures across the entire library independent from the originating source, project or assay. Access to the individual signatures also enables the newly implemented signature search functionality, which utilizes the iLINCS platform to identify conditions that mimic or reverse gene set queries, and a newly designed query interface enables global metadata search with autosuggest across all annotations associated with perturbations, model systems, and signatures. Read more “LINCS Data Portal 2.0 Update with New Functionalities” →

Publications

Drug Repositioning in Glioblastoma: A Pathway Perspective

Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current standard of care is surgical resection, radiation, and chemotherapy treatment, which extends life in most cases. Unfortunately, tumor recurrence is nearly universal and patients with recurrent glioblastoma typically survive less than one year. Read more “Drug Repositioning in Glioblastoma: A Pathway Perspective” →

Events - Past

BD2K-LINCS Data Science Symposium 1/31-2/2/18

The BD2K-LINCS Data Coordination and Integration Center (DCIC) and the University of Miami present the third annual BD2K-LINCS Data Science Symposium: Studying Systems Biology by Cellular Perturbations (DSS 2018) on January 31 – February 2, 2018. Read more “BD2K-LINCS Data Science Symposium 1/31-2/2/18” →

Lectures & Seminars - Archived

Systems Biology Data Science Symposium, 1/19-20/2016

Join us for the first Systems Biology Data Science Symposium! The BD2K-LINCS DCIC and the University of Miami will host the two-day Systems Biology Data Science Symposium (SBDSS 2016) on January 19-20, 2016. Click here to add the event to your calendar. Read more “Systems Biology Data Science Symposium, 1/19-20/2016” →

Grants

NIH Big Data to Knowledge (BD2K) Grant

Stephan Schürer, PhD, Associate Professor of Molecular and Cellular Pharmacology at the Miller School, and Chemoinformatics program leader at IDSC, is the head of the team of University of Miami researchers funded through the National Institutes of Health (NIH) who are creating a Data Coordination and Integration Center for the Library of Integrated Network-based Cellular Signatures (LINCS) program. Read more “NIH Big Data to Knowledge (BD2K) Grant” →

News - Archived

New Release of the LIFE Search Engine

A new version of the LIFE search engine has been released. LIFE makes it possible to search across data generated at the LINCS project. This new release includes recent data releases from the LINCS Consortium. It has improved search functionality and several new data visualization features. Read more “New Release of the LIFE Search Engine” →

News - Archived

Data Standards for LINCS Project Published

The National Institutes of Health Library of Integrated Network-based Cellular Signatures (LINCS) program is generating extensive multidimensional data sets, including biochemical, genome-wide transcriptional, and phenotypic cellular response signatures to a variety of small-molecule and genetic perturbations with the goal of creating a sustainable, widely applicable, and readily accessible systems biology knowledge resource. Integration and analysis of diverse LINCS data sets depend on the availability of sufficient metadata to describe the assays and screening results and on their syntactic, structural, and semantic consistency. Read more “Data Standards for LINCS Project Published” →

News - Archived

NIH funds “LIFE”

Congratulations to Drs. Stephan Schurer, Vance Lemmon, Ubbo Visser, and the Cheminformatics Group, recipients of NIH funding for their proposal entitled “LINCS Information FramEwork (LIFE) to Integrate and Analyze Diverse Data set”. This project proposes to develop a novel information system that will help scientists to access and use information generated by the NIH LINCS project and other public data sources. Read more “NIH funds “LIFE”” →

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